Systems Neuroscience and Behavior Lab

Lab Trainees and Alumni are Underlined

2023

Monge FA, Fanni AM, Donabedian PL, Hulse J, Maphis NM, Jiang S, Donaldson TN, Clark BJ, Whitten DG, Bhaskar K, Chi EY. (2023). Selective in vitro and ex vivo staining of brain neurofibrillary tangles and amyloid plaques by novel ethylene ethynylene-based optical sensors. Biosensors. 13(2): 151.

Schaeffer EA, Campbell N, Sampson H, Osterlund Oltmanns JR, Lake R, Clark BJ, Wallace DG. (2023). Cue polarization and representation in mouse home base behaviors. Animal Cognition. In Press.

2022

Osterlund Oltmanns JR, Schaeffer EA, Goncalves Garcia M, Donaldson TN, Acosta G, Sanchez LM, Davies S, Savage DD, Wallace DG, Clark BJ. (2022). Sexual dimorphisms in the effects of prenatal alcohol exposure on the organization of open field behavior. Alcoholism: Clinical and Experimental Research. 46:461-875.

Pentkowski NS, Bouquin SJ, Maestas-Olguin CR, Villaseñor ZM, Clark BJ. (2022). Differential effects of chronic stress on anxiety-like behavior and contextual fear conditioning in the TgF344-AD rat model of Alzheimer’s disease. Behavioural Brain Research. 10: 113661.

2021

Pentkowski NS, Rogge-Obando K, Donaldson TN, Bouquin SJ, Clark BJ. (2021). Anxiety and Alzheimer’s disease: behavioral analysis and neural basis in rodent models of Alzheimer’s-related neuropathology. Neuroscience & Biobehavioral Reviews. 127: 647-658.

2020

Hernandez AR, Truckenbrod LM, Barrett ME, Lubke KN, Clark BJ, Burke SN. (2020). Age-related alterations in prelimbic cortical neuron Arc expression vary by behavioral state and cortical layer. Frontiers in Aging Neuroscience. 12:588297 doi: 10.3389/fnagi.2020.588297.

Harvey RE, Berkowitz LE, Savage DD, Hamilton DA, Clark BJ. (2020). Altered hippocampal place cell representation and theta rhythmicity following moderate prenatal alcohol exposure. Current Biology. 30(18):3556-3569. Commentary: Wirt et al in Current Biology, 30(18):PR1058–PR1061

Bermudez-Contreras E, Clark BJ, Wilber AA. (2020). The neuroscience behind navigation and its relationship to artificial intelligence. Frontiers in Computational Neuroscience. 14:63.

Berkowitz LE, Harvey RE, Clark BJ. (2020). Spatial Navigation and Alzheimer’s disease. In: C. Martin & V.R. Preedy (Eds.), The Neuroscience of Dementia: Genetics, Neurology, Behavior, and Diet in Dementia (1st ed., Vol. 2, pp. 677-692). Academic Press.

Madden JT, Thompson SM, Magcalas CM, Wagner J, Hamilton DA, Savage DD, Clark BJ, Pentkowski NS. (2020). Moderate prenatal alcohol exposure reduces parvalbumin expressing GABAergic interneurons in the dorsal hippocampus of adult male and female rat offspring. Neuroscience Letters. 718:134700.

2019

Xu Z, Wu W, Winter SS, Mehlman ML, Butler WN, Simmons C, Harvey RE, Berkowitz LE, Chen Y, Taube JS, Wilber AA, Clark BJ. (2019). A comparison of neural decoding methods and population coding across thalamo-cortical head direction cells. Frontiers in Neural Circuits. 13, 75. doi: 10.3389/fncir.2019.00075

Harvey RE, Berkowitz LE, Hamilton DA, Clark BJ. (2019). The effects of developmental alcohol exposure on the neurobiology of spatial processing. Neuroscience & Biobehavioral Reviews. 107:775-794.

Yoder RM, Valerio S, Crego AC, Clark BJ, Taube JS. (2019). Bilateral postsubiculum lesions impair visual and non-visual homing performance in rats. Behavioral Neuroscience. 133(5):496-507.

Witharana WK, Clark BJ, Trivedi V, Mesina L, McNaughton BL. (2019). Immediate early gene Homer 1a intranuclear transcription focus intensity as a measure of relative neural activation. Hippocampus. 29:481-490.

Sanchez LM, Goss J, Wagner J, Davies S, Savage DD, Hamilton DA, Clark BJ. (2019). Moderate prenatal alcohol exposure impairs performance in an object-place paired-associate task. Behavioural Brain Research. 360: 228-234.

2018

Berkowitz LE, Harvey RE, Drake EN, Thompson SM, Clark BJ. (2018). Progressive impairment of directional and spatially precise trajectories by TgF344-Alzheimer’s disease rats in the Morris water task. Scientific Reports. 8:16153.

Clark BJ, Simmons CM, Berkowitz LE, Wilber AA (2018). The retrosplenial-parietal network and reference frame coordination for spatial navigation. Behavioral Neuroscience. 132: 416-429.

Hernandez AR, Reasor J, Truckenbrod LM, Campos KT, Federico QP, Fertal KE, Lubke KM, Johnson SA, Clark BJ, Maurer AP, Burke SN. (2018). Dissociable effects of advanced age on prefrontal cortical and medial temporal lobe ensemble activity. Neurobiology of Aging. 70: 217-232.

Harvey RE, Rutan SA, Willey GR, Siegel JJ, Clark BJ, Yoder RM. (2018). Linear self-motion cues support the distribution and stable firing of hippocampal place cells. Current Biology. 28: 1-8.

Pentkowski NS, Berkowitz LE, Thompson SM, Drake EN, Olguin C, Clark BJ. (2018). Anxiety-like behavior as an early endophenotype in the TgF344-AD rat model of Alzheimer’s disease. Neurobiology of Aging. 61: 169-176.

Thompson SM, Berkowitz LE, Clark BJ. (2018). Behavioral and neural subsystems of rodent exploration. Learning and Motivation. 61: 3-15.

2017

Maurer AP, Johnson SA, Hernandez AR, Reasor J, Cossio DM, Fertal KE, Mizell JM, Lubke KM, Clark BJ, Burke SN. (2017). Age-related changes in lateral entorhinal and CA3 neuron allocation predict poor performance on object discrimination. Frontiers in Systems Neuroscience. 11(49): doi: 10.3389/fnsys.2017.00049.

Clark BJ. (2017). Spatial navigation: retrosplenial cortex encodes the spatial structure of complex routes. Current Biology. 27(13):R649-R651.

Harvey RE, Thompson SM, Sanchez LM, Yoder RM, Clark BJ. (2017). Post-training inactivation of the anterior thalamic nuclei impairs spatial performance on the radial arm maze. Frontiers in Neuroscience 11: doi: 10.3389/fnins.2017.00094.

2016

Sanchez LM, Thompson SM, Clark BJ. (2016). Influence of proximal, distal, and vestibular frames of reference in object-place paired associate learning in the rat. PLoS ONE. 11(9): e0163102. doi:10.1371/journal.pone.0163102

Clark BJ, Harvey RE. (2016). Do the anterior and lateral thalamic nuclei make distinct contributions to spatial representation and memory? Neurobiology of Learning and Memory. 133:69-78.

Mesina L, Wilber AA, Clark BJ, Dube S, Demecha A, Stark CEL, McNaughton BL. (2016). A methodological pipeline for serial-section imaging and tissue realignment for whole-brain functional and connectivity assessment. Journal of Neuroscience Methods. 266:151-160.

2015

Winter SS, Mehlman ML, Clark BJ, Taube JS. (2015). Passive transport disrupts grid cell signals in the parahippocampal cortex. Current Biology, 25(19):2493–2502. Commentary: O´lafsdo´ttir & Barry in Current Biology, 25(19):R827–R844  

Clark BJ, Hong NS, Bettenson DJ, Woolford J, Horwood L, McDonald RJ. (2015). Maintained directional navigation across environments in the Morris water task is dependent on vestibular cues. Journal of Experimental Psychology: Animal Learning and Cognition, 41(3):301-308.

Winter SS*, Clark BJ*, Taube JS. (2015). Disruption of the head direction cell network impairs the parahippocampal grid cell signal. Science, 347(6224):870-874. *Contributed Equally

Wilber AA*, Clark BJ*, Demecha A, Mesina L, Voss J, McNaughton BL. (2015). Cortical connectivity maps reveal anatomically distinct areas in the parietal cortex of the rat. Frontiers in Neural Circuits, 8(146):doi: 10.3389/fncir.2014.00146. *Contributed Equally

2014

Wilber AA, Clark BJ, Forster T, Tatsuno M, McNaughton BL. (2014). Interaction of egocentric and world centered reference frames in rat posterior parietal cortex. Journal of Neuroscience, 34(16):5431-5446.

2013

Clark BJ, Rice J, Akers KG, Johnson T, Taube JS, Hamilton DA. (2013). Lesions of the dorsal tegmental nuclei disrupts control of navigation by distal landmarks in cued, directional, and place variants of the Morris water task. Behavioral Neuroscience, 127(4):566-581.

2012

Clark BJ, Brown JE, Taube JS. (2012). Head direction cell activity in the anterodorsal thalamus requires intact supragenual nuclei. Journal of Neurophysiology, 108(10):2767-2784.

Clark BJ, Taube JS. (2012). Vestibular and attractor network basis of the head direction cell signal in subcortical circuits. Frontiers in Neural Circuits, 6(7):doi: 10.3389/fncir.2012.00007.

Clark BJ, Harris MJ, Taube JS. (2012). Control of anterodorsal thalamic head direction cells by environmental boundaries: comparison with conflicting distal landmarks. Hippocampus, 22(2):172-187.

2011

Yoder RM, Clark BJ, Taube JS. (2011). Origins of landmark encoding for the brain. Trends in Neuroscience, 34(11):561-571.

Clark BJ, Taube JS. (2011). Intact landmark control and angular path integration by head direction cells in the anterodorsal thalamus after lesions of the medial entorhinal cortex. Hippocampus, 21(7):767-782.

Yoder RM, Clark BJ, Brown JE, Lamia M, Valerio S, Shinder M, Taube JS. (2011). Both visual and idiothetic cues contribute to head direction cell stability during navigation along complex routes. Journal of Neurophysiology, 105(6):2989-3001.

2010

Clark BJ, Bassett JP, Wang S, Taube JS. (2010). Impaired head direction cell representation in the anterodorsal thalamus after lesions of the retrosplenial cortex. Journal of Neuroscience, 30(15):5289-5302.

Valerio S*, Clark BJ*, Chan JHM, Frost CP, Harris MJ, Taube JS. (2010). Directional learning, but no spatial mapping by rats performing a navigational task in an inverted orientation. Neurobiology of Learning and Memory, 93(4):495-505. *Contributed Equally

2009

Clark BJ, Taube JS. (2009). Deficits in landmark navigation and path integration after lesions of the interpeduncular nucleus. Behavioral Neuroscience, 123(3):490-503.

Clark BJ, Sarma A, Taube JS. (2009). Head direction cell instability in the anterior dorsal thalamus after lesions of the interpeduncular nucleus. Journal of Neuroscience, 29(2):493-507.

2007

Lehmann H*, Clark BJ*, Whishaw IQ. (2007). Similar development of cued and conditioned home bases in control and hippocampal-damaged rats in an open field exploratory task. Hippocampus, 17(5):370-80. *Contributed Equally

2006

Whishaw IQ, Gharbawie OA, Clark BJ, Lehmann H. (2006). The exploratory behavior of rats in an open environment optimizes security. Behavioural Brain Research, 171(2):230-9.

Clark BJ, Hamilton DA, Whishaw IQ. (2006). Motor Activity (exploration) and formation of home bases in mice (C57BL/6) influenced by visual and tactile cues: modification of movement distribution, distance, location, and speed. Physiology & Behavior, 87(4):805-16.

2005

Clark BJ, Hines DJ, Hamilton DA, Whishaw IQ. (2005). Movements of exploration intact in rats with hippocampal lesions. Behavioural Brain Research, 163(1):91-9.